About Dichloroacetic Acid

What is Dichloroacetic Acid?

Also known as bichloroacetic acid (BCA), dichloroacetic acid (DCA) is a chemical compound which is an analog of acetic acid. DCA is one of the five haloacetic acids and a member of the chloroacetic acids family. It is an essential chemical compound in medical research, especially in cancer treatment. This type of chloroacetic acid is a trace product of the process of chlorination of drinking water.

What Types of Industrial Uses Does it Have?

The chemical compound is used as an intermediate in the synthesis of other organic materials. DCA is an essential ingredient in pharmaceuticals and medicines. It is also used in the manufacturing of fungicide and topical astringent.

How Does Dichloroacetic Acid Get into Your Drinking Water?

DCA can get into water systems through improper disposal of waste from pharmaceutical factories. Like other Haloacetic Acids (HAAs), it can be formed in water systems through chlorination, ozonation or chloramination of drinking water.

What are the Health Risks Associated with Dichloroacetic Acid?

Although it is used as a therapeutic agent to treat diabetes, lactic acidosis, and familial hyperlipidemia, DCA in drinking water may cause health problems during pregnancy, liver and kidney damages, reproductive difficulties, eyes and nerve problems, and an increased risk of getting cancer.

How Common is Dichloroacetic Acid in Water?

Dichloroacetic Acid is common in municipal water since it is a trace product of chlorination of drinking water.

What is the EPA’s Contamination Level Standards for Dichloroacetic Acid in Drinking Water?

The EPA’s MCLG for Dichloroacetic Acid is zero and the MCL for the contaminant is 0.060 mg/L or 60 ppb.

What is the Best Reduction Media for Removing Dichloroacetic Acid from Drinking Water?

While the best way to remove the contamination from your drinking water is by eliminating the source of the pollutant, a granular activated carbon in water filter systems can help remove DCA to below the EPA’s contamination level standards. An AquaOx water filter is equipped with premium quality GAC which will help you keep your family safe from potential chemical compounds in tap water.

Chemical Names:DICHLOROACETIC ACID; 2,2-Dichloroacetic acid; 79-43-6; Dichloracetic acid; Dichloroethanoic acid; Acetic acid, dichloro-
Molecular Formula:C2H2Cl2O2 or CHCl2COOH
Molecular Weight:128.936 g/mol
InChI Key:JXTHNDFMNIQAHM-UHFFFAOYSA-N
Drug Information:Therapeutic Uses  FDA UNII
Safety Summary:Laboratory Chemical Safety Summary (LCSS)

Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn’t designed to establish effectiveness. DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market.
Source: DrugBank
Record Name: Dichloroacetic Acid
URL: http://www.drugbank.ca/drugs/DB08809

Description: The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information

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